Human SPFH2 (ERLIN2) activation kit by CRISPRa

CAT#: GA107682

ERLIN2 CRISPRa kit - CRISPR gene activation of human ER lipid raft associated 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ERLIN2
• Locus ID: 11160
• Kit Components:

  GA107682G1, ERLIN2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107682G2, ERLIN2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107682G3, ERLIN2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001003790, NM_001003791, NM_007175, NM_001362878, NM_001362880
• Synonyms: C8orf2; Erlin-2; NET32; SPFH2; SPG18
• Summary: This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]