Human SUPT16H activation kit by CRISPRa

CAT#: GA107716

SUPT16H CRISPRa kit - CRISPR gene activation of human SPT16 homolog, facilitates chromatin remodeling subunit

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SUPT16H
• Locus ID: 11198
• Kit Components:

  GA107716G1, SUPT16H gRNA vector 1 in pCas-Guide-CRISPRa

  GA107716G2, SUPT16H gRNA vector 2 in pCas-Guide-CRISPRa

  GA107716G3, SUPT16H gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007192
• Synonyms: CDC68; FACTP140; SPT16; SPT16/CDC68
• Summary: Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]