Human Kallikrein 8 (KLK8) activation kit by CRISPRa

CAT#: GA107720

KLK8 CRISPRa kit - CRISPR gene activation of human kallikrein related peptidase 8

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KLK8
• Locus ID: 11202
• Kit Components:

  GA107720G1, KLK8 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107720G2, KLK8 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107720G3, KLK8 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001281431, NM_007196, NM_144505, NM_144506, NM_144507, NR_104008
• Synonyms: HNP; NP; NRPN; PRSS19; TADG14
• Summary: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]