Human EAP30 (SNF8) activation kit by CRISPRa

CAT#: GA107764

SNF8 CRISPRa kit - CRISPR gene activation of human SNF8 subunit of ESCRT-II

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SNF8
• Locus ID: 11267
• Kit Components:

  GA107764G1, SNF8 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107764G2, SNF8 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107764G3, SNF8 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001317192, NM_001317193, NM_001317194, NM_007241, NR_133679
• Synonyms: Dot3; EAP30; VPS22
• Summary: The protein encoded by this gene is a component of the endosomal sorting complex required for transport II (ESCRT-II), which regulates the movement of ubiquitinylated transmembrane proteins to the lysosome for degradation. This complex also interacts with the RNA polymerase II elongation factor (ELL) to overcome the repressive effects of ELL on RNA polymerase II activity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]