Human KLHL2 activation kit by CRISPRa

CAT#: GA107770

KLHL2 CRISPRa kit - CRISPR gene activation of human kelch like family member 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KLHL2
• Locus ID: 11275
• Kit Components:

  GA107770G1, KLHL2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107770G2, KLHL2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107770G3, KLHL2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001161521, NM_001161522, NM_007246, NM_001331023, NM_001331024
• Synonyms: ABP-KELCH; MAV; MAYVEN
• Summary: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors. [UniProtKB/Swiss-Prot Function]