Human SCN11A activation kit by CRISPRa

CAT#: GA107775

SCN11A CRISPRa kit - CRISPR gene activation of human sodium voltage-gated channel alpha subunit 11

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SCN11A
• Locus ID: 11280
• Kit Components:

  GA107775G1, SCN11A gRNA vector 1 in pCas-Guide-CRISPRa

  GA107775G2, SCN11A gRNA vector 2 in pCas-Guide-CRISPRa

  GA107775G3, SCN11A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001287223, NM_014139, NM_001349253
• Synonyms: FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A; SNS-2
• Summary: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is highly expressed in nociceptive neurons of dorsal root ganglia and trigeminal ganglia. It mediates brain-derived neurotrophic factor-evoked membrane depolarization and is a major effector of peripheral inflammatory pain hypersensitivity. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy type VII and familial episodic pain syndrome-3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]