Human PARK7 activation kit by CRISPRa

CAT#: GA107785

PARK7 CRISPRa kit - CRISPR gene activation of human Parkinsonism associated deglycase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PARK7
• Locus ID: 11315
• Kit Components:

  GA107785G1, PARK7 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107785G2, PARK7 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107785G3, PARK7 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001123377, NM_007262
• Synonyms: DJ-1; DJ1; HEL-S-67p
• Summary: The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]