Human HP1 gamma (CBX3) activation kit by CRISPRa

CAT#: GA107802

CBX3 CRISPRa kit - CRISPR gene activation of human chromobox 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CBX3
• Locus ID: 11335
• Kit Components:

  GA107802G1, CBX3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107802G2, CBX3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107802G3, CBX3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007276, NM_016587
• Synonyms: HECH; HP1-GAMMA; HP1Hs-gamma
• Summary: At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene. [provided by RefSeq, Mar 2011]