Human Monoacylglycerol Lipase (MGLL) activation kit by CRISPRa

CAT#: GA107810

MGLL CRISPRa kit - CRISPR gene activation of human monoglyceride lipase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MGLL
• Locus ID: 11343
• Kit Components:

  GA107810G1, MGLL gRNA vector 1 in pCas-Guide-CRISPRa

  GA107810G2, MGLL gRNA vector 2 in pCas-Guide-CRISPRa

  GA107810G3, MGLL gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001003794, NM_001256585, NM_007283
• Synonyms: HU-K5; HUK5; MAGL; MGL
• Summary: This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]