Human LPHN1 (ADGRL1) activation kit by CRISPRa

CAT#: GA107859

ADGRL1 CRISPRa kit - CRISPR gene activation of human adhesion G protein-coupled receptor L1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ADGRL1
• Locus ID: 22859
• Kit Components:

  GA107859G1, ADGRL1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107859G2, ADGRL1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107859G3, ADGRL1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001008701, NM_014921
• Synonyms: CIRL1; CL1; LEC2; LPHN1
• Summary: This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]