Human NALP1 (NLRP1) activation kit by CRISPRa

CAT#: GA107860

NLRP1 CRISPRa kit - CRISPR gene activation of human NLR family pyrin domain containing 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NLRP1
• Locus ID: 22861
• Kit Components:

  GA107860G1, NLRP1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107860G2, NLRP1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107860G3, NLRP1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001033053, NM_014922, NM_033004, NM_033005, NM_033006, NM_033007
• Synonyms: CARD7; CIDED; CLR17.1; DEFCAP; DEFCAP-L/S; NAC; NALP1; PP1044; SLEV1; VAMAS1
• Summary: This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]