Human CNKSR2 activation kit by CRISPRa

CAT#: GA107865

CNKSR2 CRISPRa kit - CRISPR gene activation of human connector enhancer of kinase suppressor of Ras 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CNKSR2
• Locus ID: 22866
• Kit Components:

  GA107865G1, CNKSR2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107865G2, CNKSR2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107865G3, CNKSR2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001168647, NM_001168648, NM_001168649, NM_001330770, NM_001330771, NM_001330772, NM_001330773, NM_014927
• Synonyms: CNK2; KSR2; MAGUIN
• Summary: This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]