Human SACM1L activation kit by CRISPRa

CAT#: GA107903

SACM1L CRISPRa kit - CRISPR gene activation of human SAC1 like phosphatidylinositide phosphatase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SACM1L
• Locus ID: 22908
• Kit Components:

  GA107903G1, SACM1L gRNA vector 1 in pCas-Guide-CRISPRa

  GA107903G2, SACM1L gRNA vector 2 in pCas-Guide-CRISPRa

  GA107903G3, SACM1L gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001319072, NM_001319073, NM_014016, NM_001319071
• Synonyms: SAC1
• Summary: This gene encodes an integral membrane protein, which is localized to the endoplasmic reticulum, and functions as a phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol 3,5-bisphosphate. Deletion of this gene in mouse results in preimplantation lethality. Other studies suggest that this gene is also involved in the organization of golgi membranes and mitotic spindles. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame, downstream translation termination codon via a stop codon readthrough mechanism. [provided by RefSeq, Dec 2017]