Human SIRT2 activation kit by CRISPRa

CAT#: GA107924

SIRT2 CRISPRa kit - CRISPR gene activation of human sirtuin 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SIRT2
• Locus ID: 22933
• Kit Components:

  GA107924G1, SIRT2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107924G2, SIRT2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107924G3, SIRT2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001193286, NM_012237, NM_030593, NR_034146
• Synonyms: SIR2; SIR2L; SIR2L2
• Summary: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]