Human SCAP activation kit by CRISPRa

CAT#: GA107927

SCAP CRISPRa kit - CRISPR gene activation of human SREBF chaperone

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SCAP
• Locus ID: 22937
• Kit Components:

  GA107927G1, SCAP gRNA vector 1 in pCas-Guide-CRISPRa

  GA107927G2, SCAP gRNA vector 2 in pCas-Guide-CRISPRa

  GA107927G3, SCAP gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001320044, NM_012235
• Summary: This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]