Human NCOA62 (SNW1) activation kit by CRISPRa

CAT#: GA107928

SNW1 CRISPRa kit - CRISPR gene activation of human SNW domain containing 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SNW1
• Locus ID: 22938
• Kit Components:

  GA107928G1, SNW1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107928G2, SNW1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107928G3, SNW1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001318844, NM_012245
• Synonyms: Bx42; NCOA-62; Prp45; PRPF45; SKIIP; SKIP
• Summary: This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]