Human Acinus (ACIN1) activation kit by CRISPRa

CAT#: GA107948

ACIN1 CRISPRa kit - CRISPR gene activation of human apoptotic chromatin condensation inducer 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ACIN1
• Locus ID: 22985
• Kit Components:

  GA107948G1, ACIN1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107948G2, ACIN1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107948G3, ACIN1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001164814, NM_001164815, NM_001164816, NM_001164817, NM_014977
• Synonyms: ACINUS; ACN; fSAP152
• Summary: Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]