Human RIM1 (RIMS1) activation kit by CRISPRa

CAT#: GA107960

RIMS1 CRISPRa kit - CRISPR gene activation of human regulating synaptic membrane exocytosis 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RIMS1
• Locus ID: 22999
• Kit Components:

  GA107960G1, RIMS1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107960G2, RIMS1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107960G3, RIMS1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001168407, NM_001168408, NM_001168409, NM_001168410, NM_001168411, NM_014989, NM_001350411, NM_001350412, NM_001350413, NM_001350414, NM_001350415, NM_001350416, NM_001350417, NM_001350418, NM_001350419, NM_001350420, NM_001350421, NM_001350422, NM_001350423, NM_001350424, NM_001350425, NM_001350426, NM_001350427, NM_001350428, NM_001350429, NM_001350430, NM_001350431, NM_001350432, NM_001350433, NM_001350434, NM_001350435, NM_001350436, NM_001350437, NM_001350438, NM_001350439, NM_001350440, NM_001350441, NM_001350442, NM_001350443, NM_001350444, NM_001350445, NM_001350446, NM_001350447, NM_001350448, NM_001350449, NM_001350450, NM_001350452, NM_001350454, NM_001350455, NM_001350456, NM_001350457, NM_001350458, NM_001350459, NM_001350460, NM_001350461, NM_001350462, NM_001350463, NM_001350464, NM_001350465, NM_001350466, NM_001350467, NM_001350468, NM_001350469, NM_001350470, NM_001350471, NM_001350472, NM_001350473, NM_001350474
• Synonyms: CORD7; RAB3IP2; RIM; RIM1
• Summary: The protein encoded by this gene is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. This gene also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]