Human MYCBP2 activation kit by CRISPRa

CAT#: GA108020

MYCBP2 CRISPRa kit - CRISPR gene activation of human MYC binding protein 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MYCBP2
• Locus ID: 23077
• Kit Components:

  GA108020G1, MYCBP2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108020G2, MYCBP2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108020G3, MYCBP2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_015057
• Synonyms: PAM
• Summary: This gene encodes an E3 ubiquitin-protein ligase and member of the PHR (Phr1/MYCBP2, highwire and RPM-1) family of proteins. The encoded protein plays a role in axon guidance and synapse formation in the developing nervous system. In mammalian cells, this protein regulates the cAMP and mTOR signaling pathways, and may additionally regulate autophagy. Reduced expression of this gene has been observed in acute lymphoblastic leukemia patients and a mutation in this gene has been identified in patients with a rare inherited vision defect. [provided by RefSeq, Mar 2017]