Human GRAF (ARHGAP26) activation kit by CRISPRa

CAT#: GA108031

ARHGAP26 CRISPRa kit - CRISPR gene activation of human Rho GTPase activating protein 26

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ARHGAP26
• Locus ID: 23092
• Kit Components:

  GA108031G1, ARHGAP26 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108031G2, ARHGAP26 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108031G3, ARHGAP26 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001135608, NM_015071, NM_001349547, NR_146198
• Synonyms: GRAF; GRAF1; OPHN1L; OPHN1L1
• Summary: Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]