Human PHF8 activation kit by CRISPRa

CAT#: GA108062

PHF8 CRISPRa kit - CRISPR gene activation of human PHD finger protein 8

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PHF8
• Locus ID: 23133
• Kit Components:

  GA108062G1, PHF8 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108062G2, PHF8 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108062G3, PHF8 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001184896, NM_001184897, NM_001184898, NM_015107
• Synonyms: JHDM1F; MRXSSD; ZNF422
• Summary: The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. The protein has an N-terminal PHD finger and a central Jumonji C domain. This gene is thought to function as a transcription activator. Defects in this gene are a cause of syndromic X-linked Siderius type intellectual disability (MRXSSD) and over-expression of this gene is associated with several forms of cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]