Human SNX13 activation kit by CRISPRa

CAT#: GA108083

SNX13 CRISPRa kit - CRISPR gene activation of human sorting nexin 13

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SNX13
• Locus ID: 23161
• Kit Components:

  GA108083G1, SNX13 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108083G2, SNX13 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108083G3, SNX13 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_015132, NM_001350862, NM_001350863, NM_001350864, NM_001350865, NM_001350866, NM_001350867, NM_001350868, NM_001350870, NR_146933, NR_146932
• Synonyms: RGS-PX1
• Summary: This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008]