Human ANKRD15 (KANK1) activation kit by CRISPRa

CAT#: GA108108

KANK1 CRISPRa kit - CRISPR gene activation of human KN motif and ankyrin repeat domains 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KANK1
• Locus ID: 23189
• Kit Components:

  GA108108G1, KANK1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108108G2, KANK1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108108G3, KANK1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001256876, NM_001256877, NM_015158, NM_153186, NM_001354331, NM_001354332, NM_001354333, NM_001354334, NM_001354335, NM_001354336, NM_001354337, NM_001354338, NM_001354339, NM_001354340, NM_001354341, NM_001354342, NM_001354343, NM_001354344, NR_148869
• Synonyms: ANKRD15; CPSQ2; KANK
• Summary: The protein encoded by this gene belongs to the Kank family of proteins, which contain multiple ankyrin repeat domains. This family member functions in cytoskeleton formation by regulating actin polymerization. This gene is a candidate tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder. A t(5;9) translocation results in fusion of the platelet-derived growth factor receptor beta gene (PDGFRB) on chromosome 5 with this gene in a myeloproliferative neoplasm featuring severe thrombocythemia. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2014]