Human Sulfatase 1 (SULF1) activation kit by CRISPRa

CAT#: GA108130

SULF1 CRISPRa kit - CRISPR gene activation of human sulfatase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SULF1
• Locus ID: 23213
• Kit Components:

  GA108130G1, SULF1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108130G2, SULF1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108130G3, SULF1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001128204, NM_001128205, NM_001128206, NM_015170, NR_132437, NR_156415, NR_156414
• Synonyms: HSULF-1; SULF-1
• Summary: This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]