Human POFUT2 activation kit by CRISPRa

CAT#: GA108183

POFUT2 CRISPRa kit - CRISPR gene activation of human protein O-fucosyltransferase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: POFUT2
• Locus ID: 23275
• Kit Components:

  GA108183G1, POFUT2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108183G2, POFUT2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108183G3, POFUT2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_015227, NM_133634, NM_133635, NR_004858, NR_148026
• Synonyms: C21orf80; FUT13
• Summary: Fucose is typically found as a terminal modification of branched chain glycoconjugates, but it also exists in direct O-linkage to serine or threonine residues within cystine knot motifs in epidermal growth factor (EGF; MIM 131530)-like repeats or thrombospondin (THBS; see MIM 188060) type-1 repeats. POFUT2 is an O-fucosyltransferase that use THBS type-1 repeats as substrates (Luo et al., 2006 [PubMed 16464857]). [supplied by OMIM, Mar 2008]