Human RNF86 (TRIM2) activation kit by CRISPRa

CAT#: GA108217

TRIM2 CRISPRa kit - CRISPR gene activation of human tripartite motif containing 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TRIM2
• Locus ID: 23321
• Kit Components:

  GA108217G1, TRIM2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108217G2, TRIM2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108217G3, TRIM2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001130067, NM_001302692, NM_001302693, NM_001302694, NM_015271, NM_001351054, NM_001351055, NM_001351056, NM_001351057
• Synonyms: CMT2R; RNF86
• Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]