Human LARG (ARHGEF12) activation kit by CRISPRa

CAT#: GA108252

ARHGEF12 CRISPRa kit - CRISPR gene activation of human Rho guanine nucleotide exchange factor 12

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ARHGEF12
• Locus ID: 23365
• Kit Components:

  GA108252G1, ARHGEF12 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108252G2, ARHGEF12 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108252G3, ARHGEF12 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001198665, NM_001301084, NM_015313
• Synonyms: LARG; PRO2792
• Summary: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]