Human p114RhoGEF (ARHGEF18) activation kit by CRISPRa

CAT#: GA108257

ARHGEF18 CRISPRa kit - CRISPR gene activation of human Rho/Rac guanine nucleotide exchange factor 18

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ARHGEF18
• Locus ID: 23370
• Kit Components:

  GA108257G1, ARHGEF18 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108257G2, ARHGEF18 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108257G3, ARHGEF18 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001130955, NM_015318, NM_001367823, NM_001367824
• Synonyms: P114-RhoGEF
• Summary: Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GEF family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Nov 2018]