Human TC10 (RHOQ) activation kit by CRISPRa

CAT#: GA108307

RHOQ CRISPRa kit - CRISPR gene activation of human ras homolog family member Q

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RHOQ
• Locus ID: 23433
• Kit Components:

  GA108307G1, RHOQ gRNA vector 1 in pCas-Guide-CRISPRa

  GA108307G2, RHOQ gRNA vector 2 in pCas-Guide-CRISPRa

  GA108307G3, RHOQ gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_012249
• Synonyms: ARHQ; HEL-S-42; RASL7A; TC10; TC10A
• Summary: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011]