Human QPRT activation kit by CRISPRa

CAT#: GA108332

QPRT CRISPRa kit - CRISPR gene activation of human quinolinate phosphoribosyltransferase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: QPRT
• Locus ID: 23475
• Kit Components:

  GA108332G1, QPRT gRNA vector 1 in pCas-Guide-CRISPRa

  GA108332G2, QPRT gRNA vector 2 in pCas-Guide-CRISPRa

  GA108332G3, QPRT gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001318249, NM_001318250, NM_014298, NR_134536
• Synonyms: HEL-S-90n; QPRTase
• Summary: This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]