Human ISCU activation kit by CRISPRa
CAT#: GA108335
ISCU CRISPRa kit - CRISPR gene activation of human iron-sulfur cluster assembly enzyme
Find the corresponding CRISPRi Inhibitor Kit
USD 1,290.00
2 Weeks*
Specifications
Product Data | |
Format | 3gRNAs, 1 scramble ctrl and 1 enhancer vector |
Symbol | ISCU |
Locus ID | 23479 |
Kit Components | GA108335G1, ISCU gRNA vector 1 in pCas-Guide-CRISPRa GA108335G2, ISCU gRNA vector 2 in pCas-Guide-CRISPRa GA108335G3, ISCU gRNA vector 3 in pCas-Guide-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100058 |
Disclaimer | The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001301140, NM_001301141, NM_001320042, NM_014301, NM_213595, NR_135127 |
Synonyms | 2310020H20Rik; HML; hnifU; ISU2; NIFU; NIFUN |
Summary | This gene encodes a component of the iron-sulfur (Fe-S) cluster scaffold. Fe-S clusters are cofactors that play a role in the function of a diverse set of enzymes, including those that regulate metabolism, iron homeostasis, and oxidative stress response. Alternative splicing results in transcript variants encoding different protein isoforms that localize either to the cytosol or to the mitochondrion. Mutations in this gene have been found in patients with hereditary myopathy with lactic acidosis. A disease-associated mutation in an intron may activate a cryptic splice site, resulting in the production of a splice variant encoding a putatively non-functional protein. A pseudogene of this gene is present on chromosome 1. [provided by RefSeq, Feb 2016] |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN404236 | ISCU - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,290.00 |
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