Human SNAPIN activation kit by CRISPRa

CAT#: GA108397

SNAPIN CRISPRa kit - CRISPR gene activation of human SNAP associated protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SNAPIN
• Locus ID: 23557
• Kit Components:

  GA108397G1, SNAPIN gRNA vector 1 in pCas-Guide-CRISPRa

  GA108397G2, SNAPIN gRNA vector 2 in pCas-Guide-CRISPRa

  GA108397G3, SNAPIN gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_012437, NR_052019, NR_052020
• Synonyms: BLOC1S7; BLOS7; BORCS3; SNAPAP
• Summary: The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1 complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules. Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]