Human ARL2BP activation kit by CRISPRa

CAT#: GA108406

ARL2BP CRISPRa kit - CRISPR gene activation of human ADP ribosylation factor like GTPase 2 binding protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ARL2BP
• Locus ID: 23568
• Kit Components:

  GA108406G1, ARL2BP gRNA vector 1 in pCas-Guide-CRISPRa

  GA108406G2, ARL2BP gRNA vector 2 in pCas-Guide-CRISPRa

  GA108406G3, ARL2BP gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_012106
• Synonyms: BART; BART1; RP66
• Summary: ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity. [provided by RefSeq, Jul 2008]