Human DPS1 (PDSS1) activation kit by CRISPRa

CAT#: GA108419

PDSS1 CRISPRa kit - CRISPR gene activation of human decaprenyl diphosphate synthase subunit 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PDSS1
• Locus ID: 23590
• Kit Components:

  GA108419G1, PDSS1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108419G2, PDSS1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108419G3, PDSS1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014317, NM_001321978, NM_001321979
• Synonyms: COQ1; COQ10D2; DPS; hDPS1; SPS; TPRT; TPT; TPT 1
• Summary: The protein encoded by this gene is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. The protein may be peripherally associated with the inner mitochondrial membrane, though no transit peptide has been definitively identified to date. Defects in this gene are a cause of coenzyme Q10 deficiency. [provided by RefSeq, Jul 2008]