Human MAN1 (LEMD3) activation kit by CRISPRa

CAT#: GA108420

LEMD3 CRISPRa kit - CRISPR gene activation of human LEM domain containing 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LEMD3
• Locus ID: 23592
• Kit Components:

  GA108420G1, LEMD3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108420G2, LEMD3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108420G3, LEMD3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001167614, NM_014319
• Synonyms: MAN1
• Summary: This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis. [provided by RefSeq, Nov 2009]