Human ZIM2 activation kit by CRISPRa

CAT#: GA108438

ZIM2 CRISPRa kit - CRISPR gene activation of human zinc finger imprinted 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ZIM2
• Locus ID: 23619
• Kit Components:

  GA108438G1, ZIM2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108438G2, ZIM2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108438G3, ZIM2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001146326, NM_001146327, NM_015363, NM_001369772, NM_001369773, NR_163141, NR_163142, NM_001369770, NM_001369771, NM_001369774, NR_163140, NR_163143
• Synonyms: ZNF656
• Summary: In human, ZIM2 and PEG3 (GeneID:5178) are two distinct genes that share a set of 5' exons and have a common promoter, and both genes are paternally expressed. Alternative splicing events connect the shared exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. This is in contrast to mouse and cow, where ZIM2 and PEG3 genes do not share exons in common, and the imprinting status of ZIM2 is also not conserved amongst mammals. Additional 5' alternatively spliced transcripts encoding the same protein have been found for the human ZIM2 gene. [provided by RefSeq, Oct 2010]