Human HSPBP1 activation kit by CRISPRa

CAT#: GA108453

HSPBP1 CRISPRa kit - CRISPR gene activation of human HSPA (Hsp70) binding protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HSPBP1
• Locus ID: 23640
• Kit Components:

  GA108453G1, HSPBP1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108453G2, HSPBP1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108453G3, HSPBP1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001130106, NM_001297600, NM_012267
• Synonyms: FES1
• Summary: Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR. [UniProtKB/Swiss-Prot Function]