Human xCT (SLC7A11) activation kit by CRISPRa

CAT#: GA108464

SLC7A11 CRISPRa kit - CRISPR gene activation of human solute carrier family 7 member 11

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SLC7A11
• Locus ID: 23657
• Kit Components:

  GA108464G1, SLC7A11 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108464G2, SLC7A11 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108464G3, SLC7A11 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014331
• Synonyms: CCBR1; xCT
• Summary: This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]