Human CEMIP2 activation kit by CRISPRa

CAT#: GA108468

CEMIP2 CRISPRa kit - CRISPR gene activation of human cell migration inducing hyaluronidase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TMEM2
• Locus ID: 23670
• Kit Components:

  GA108468G1, TMEM2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108468G2, TMEM2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108468G3, TMEM2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001135820, NM_013390, NM_001349784
• Synonyms: OTTHUMP00000021450; transmembrane protein 2
• Summary: This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss. [provided by RefSeq, Mar 2017]