Human ARHGAP8 activation kit by CRISPRa

CAT#: GA108500

ARHGAP8 CRISPRa kit - CRISPR gene activation of human Rho GTPase activating protein 8

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ARHGAP8
• Locus ID: 23779
• Kit Components:

  GA108500G1, ARHGAP8 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108500G2, ARHGAP8 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108500G3, ARHGAP8 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001017526, NM_001198726, NM_017701, NM_181335
• Synonyms: BPGAP1; PP610
• Summary: This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]