Human SPDEF activation kit by CRISPRa

CAT#: GA108548

SPDEF CRISPRa kit - CRISPR gene activation of human SAM pointed domain containing ETS transcription factor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SPDEF
• Locus ID: 25803
• Kit Components:

  GA108548G1, SPDEF gRNA vector 1 in pCas-Guide-CRISPRa

  GA108548G2, SPDEF gRNA vector 2 in pCas-Guide-CRISPRa

  GA108548G3, SPDEF gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001252294, NM_012391
• Synonyms: bA375E1.3; PDEF
• Summary: The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]