Human Kallikrein 5 (KLK5) activation kit by CRISPRa

CAT#: GA108558

KLK5 CRISPRa kit - CRISPR gene activation of human kallikrein related peptidase 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KLK5
• Locus ID: 25818
• Kit Components:

  GA108558G1, KLK5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108558G2, KLK5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108558G3, KLK5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001077491, NM_001077492, NM_012427
• Synonyms: KLK-L2; KLKL2; SCTE
• Summary: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]