Human Pirh2 (RCHY1) activation kit by CRISPRa

CAT#: GA108615

RCHY1 CRISPRa kit - CRISPR gene activation of human ring finger and CHY zinc finger domain containing 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RCHY1
• Locus ID: 25898
• Kit Components:

  GA108615G1, RCHY1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108615G2, RCHY1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108615G3, RCHY1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001008925, NM_001009922, NM_001278536, NM_001278537, NM_001278538, NM_001278539, NM_015436, NR_037913, NR_037914, NR_103723, NR_103724, NR_103725
• Synonyms: ARNIP; CHIMP; hARNIP; PIRH2; PIRH2E; PIRH2F; PRO1996; RNF199; ZNF363
• Summary: The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]