Human TMEM158 activation kit by CRISPRa

CAT#: GA108622

TMEM158 CRISPRa kit - CRISPR gene activation of human transmembrane protein 158 (gene/pseudogene)

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TMEM158
• Locus ID: 25907
• Kit Components:

  GA108622G1, TMEM158 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108622G2, TMEM158 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108622G3, TMEM158 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_015444
• Synonyms: BBP; p40BBP; RIS1
• Summary: Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under other conditions that induce senescence. The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway. An allelic polymorphism in this gene results in both functional and non-functional (frameshifted) alleles; the reference genome represents the functional allele. [provided by RefSeq, Jul 2015]