Human POT1 activation kit by CRISPRa

CAT#: GA108626

POT1 CRISPRa kit - CRISPR gene activation of human protection of telomeres 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: POT1
• Locus ID: 25913
• Kit Components:

  GA108626G1, POT1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108626G2, POT1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108626G3, POT1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001042594, NM_015450, NR_003102, NR_003103, NR_003104
• Synonyms: CMM10; GLM9; HPOT1
• Summary: This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]