Human COBRA1 (NELFB) activation kit by CRISPRa

CAT#: GA108630

NELFB CRISPRa kit - CRISPR gene activation of human negative elongation factor complex member B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NELFB
• Locus ID: 25920
• Kit Components:

  GA108630G1, NELFB gRNA vector 1 in pCas-Guide-CRISPRa

  GA108630G2, NELFB gRNA vector 2 in pCas-Guide-CRISPRa

  GA108630G3, NELFB gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_015456
• Synonyms: COBRA1; NELF-B
• Summary: NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]). [supplied by OMIM, Mar 2008]