Human SOSTDC1 activation kit by CRISPRa

CAT#: GA108637

SOSTDC1 CRISPRa kit - CRISPR gene activation of human sclerostin domain containing 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SOSTDC1
• Locus ID: 25928
• Kit Components:

  GA108637G1, SOSTDC1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108637G2, SOSTDC1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108637G3, SOSTDC1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_015464
• Synonyms: CDA019; ECTODIN; USAG1
• Summary: This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [provided by RefSeq, Jul 2008]