Human Gemin 5 (GEMIN5) activation kit by CRISPRa

CAT#: GA108638

GEMIN5 CRISPRa kit - CRISPR gene activation of human gem nuclear organelle associated protein 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GEMIN5
• Locus ID: 25929
• Kit Components:

  GA108638G1, GEMIN5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108638G2, GEMIN5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108638G3, GEMIN5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001252156, NM_015465
• Synonyms: GEMIN-5
• Summary: This gene encodes a WD repeat protein that is a component of the survival of motor neurons (SMN) complex. The SMN complex plays a critical role in mRNA splicing through the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), and may also mediate the assembly and transport of other classes of ribonucleoproteins. The encoded protein is the snRNA-binding component of the SMN complex. Dysregulation of this gene may play a role in alternative mRNA splicing and tumor cell motility. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]