Human NSL1 activation kit by CRISPRa

CAT#: GA108642

NSL1 CRISPRa kit - CRISPR gene activation of human NSL1 component of MIS12 kinetochore complex

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NSL1
• Locus ID: 25936
• Kit Components:

  GA108642G1, NSL1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108642G2, NSL1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108642G3, NSL1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001042549, NM_001297736, NM_001297737, NM_001297739, NM_015471
• Synonyms: C1orf48; DC8; MIS14
• Summary: This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. There is a pseudogene of the 3' UTR region of this gene on chromosome X. [provided by RefSeq, Jul 2014]