Human MMACHC activation kit by CRISPRa

CAT#: GA108667

MMACHC CRISPRa kit - CRISPR gene activation of human metabolism of cobalamin associated C

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MMACHC
• Locus ID: 25974
• Kit Components:

  GA108667G1, MMACHC gRNA vector 1 in pCas-Guide-CRISPRa

  GA108667G2, MMACHC gRNA vector 2 in pCas-Guide-CRISPRa

  GA108667G3, MMACHC gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_015506, NM_001330540
• Synonyms: cblC
• Summary: The exact function of the protein encoded by this gene is not known, however, its C-terminal region shows similarity to TonB, a bacterial protein involved in energy transduction for cobalamin (vitamin B12) uptake. Hence, it is postulated that this protein may have a role in the binding and intracellular trafficking of cobalamin. Mutations in this gene are associated with methylmalonic aciduria and homocystinuria type cblC. [provided by RefSeq, Oct 2009]